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Evidence Base

Resources that provide research evidence and data related to opioids and the extent of and response to the crisis.

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Lives Lost to Opioid Toxicity among Ontarians Who Worked in the Construction IndustryInfographic about the impact of drug toxicity and the opioid crisis on construction workers.Ontario Drug Policy Research Network
Changes in drug prescribing to seniors in CanadaSummary of findings from a report about the drugs most commonly prescribed to seniors in Canada, including those living in long-term care facilities.Canadian Institute for Health Information
Closing Gaps, Reducing Barriers: Expanding the Response to the Toxic Drug and Overdose CrisisReport by the Select Standing Committee on Health in British Columbia that examines and makes recommendations about the urgent and ongoing illicit drug toxicity and overdose crisis.Legislative Assembly of British Columbia
Simcoe Muskoka Opioid Strategy: A Report on Actions 2018-2021Report on the implementation of the Simcoe Muskoka Pillar Actions (2018-2021). Includes data on the opioid-related harms. This report provides a status update on the activities and data on opioid related harms.Simcoe Muskoka Opioid Strategy Steering Committee
Experiences of Harm Reduction Service Providers During Dual Public Health Emergencies in CanadaReport highlights the experiences of harm reduction workers during the overdose emergency and COVID-19 pandemic, and the impact on those providing services.Canadian Centre on Substance Use and Addiction
Joint Statement from the Co-Chairs of the Special Advisory Committee on the Epidemic of Opioid Overdoses – Latest National Data on Substance-Related HarmsGovernment of Canada statement on surveillance data about opioid- and stimulant-related harms from January 2016 to December 2021 and projections to December 2022. Statement includes links to information about related topics, including naloxone and stigma.Public Health Agency of Canada
Experiences of Harm Reduction Service Providers During Dual Public Health Emergencies in CanadaReport highlights the experiences of harm reduction workers during the overdose emergency and COVID-19 pandemic, and the impact on those providing services.Canadian Centre on Substance Use and Addiction
Clinical outcomes and health care costs among people entering a safer opioid supply program in OntarioWebpage with links to infographic and research article evaluating the impact of Canada’s first safer opioid supply program on health service use and costs.Ontario Drug Policy Research Network
Interactive map: Canada's response to the opioid crisisMap of opioid prevention, harm reduction, treatment and enforcement in communities across Canada.Health Canada
Substance use surveillance data: Reporting the prescribing patterns, use/misuse, drug overdoses and deaths related to fentanyl and opioids in AlbertaSubstance use data to help the government better understand the addiction challenges in Alberta and make informed, strategic decisions about how best to create a recovery-oriented system of care that supports individuals experiencing addiction.Government of Alberta
Toronto Overdose Action Plan: Status Report 2021Status report on actions taken to implement the Toronto Overdose Action Plan with recommendations for actions to mitigate the harms from drugs that are worsening during the COVID-19 pandemic.City of Toronto
Modelling opioid-related deaths during the COVID-19 outbreakReport on simulation model of opioid-related deaths that provided information on the number of these deaths that might occur during the COVID-19 outbreak in 2020 through to June 2022.Public Health Agency of Canada
Overdose Response Indicator ReportProvincial surveillance report providing current data on key overdose-related indicators.BC Centre for Disease Control
Renewed Focus: A Follow-up Report on Youth Opioid use in AlbertaFollow up and progress assessment of the recommendations made in the 2018 report that brought attention to the need for a youth-specific response to the opioid crisisOffice of the Child and Youth Advocate Alberta
Patterns of Medication and Healthcare Use among People who Died of an Opioid-Related Toxicity during the COVID-19 Pandemic in OntarioDescribes patterns of medication and healthcare use among people who died of an opioid-related toxicity in Ontario during the COVID-19 pandemic, including a discussion of the characteristics and patterns of healthcare use among people who were experiencing homelessness.Ontario Drug Policy Research Network
The Opioid Crisis in CanadaIntroduction to selected health aspects of the opioid crisis in Canada, including key statistics, considerations related to the impact of the crisis on different groups of people, and information about recent federal initiatives and activities in the Parliament of Canada intended to address the crisis.Library of Parliament
Safer Opioid Supply Program: Preliminary ReportEvaluation of a program using a harm reduction approach to reduce health risks associated with substance use, and examine potential for scaling the program up.London InterCommunity Health Program
Toronto Shelter-Hotel Overdose Preparedness Assessment ProjectEvaluation of the Toronto Shelter-Hotel Overdose Preparedness Assessment Project with recommendations for future projects.Toronto Shelter-Hotel Overdose Action Task Force
“They treat you with such disdain:” Experiences of overdose among people who inject drugsCaptures and explores the experience of overdose of people who live in Ontario, including what happened, where, and how others responded to help. Includes suggestions for improvement.MAP Centre for Urban Health Solutions
Early Findings from Safer Supply Pilot ProjectsSummary of evaluation of Canada's safer supply pilot projects with lessons learned related to design and implementation.Health Canada
Assessment of the Implementation of Safer Supply Pilot ProjectsQualitative evaluation of Canada's safer supply pilot projects with lessons learned related to design and implementation.Controlled Substances and Cannabis Branch, Health Canada
Report of an Evaluation of Manitoba Harm Reduction Network Services in the Context of the COVID-19 PandemicDiscusses the impact of the COVID-19 pandemic on harm reduction services in Manitoba and identifies best practices for harm reduction providers.National Collaborating Centre for Infectious Diseases
Smoking OpioidsData from the BC Harm Reduction Client Survey on administration of opioids via smoking.BC Centre for Disease Control
Alberta opioid response surveillance reportSurveillance report presenting emergency department, prescription and mortality data associated with fentanyl, other opioids and other substances in Alberta.Government of Alberta
Opioid Related Harms in New BrunswickQuarterly surveillance reports describing data on apparent opioid overdoses and deaths in New Brunswick, along with data on the take-home naloxone kit distribution and use.Office of the Chief Medical Officer of Health of New Brunswick
Rapid Review Update 1: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms?Rapid review that seeks to identify, appraise and summarize emerging research evidence to support evidence-informed decision making.National Collaborating Center on Methods and Tools
Opioid Mortality Trends in Ontario in the Context of COVID-19 PandemicWebinar and slides presenting key data.Office of the Chief Coroner for Ontario
Vancouver Island Drug Checking ProjectReport of recent findings from drug checking services on Vancouver Island.University of Victoria
Rapid Review Update 1: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms?A rapid review supporting public health decision makers’ response to the COVID-19 pandemic in the context of the opioid crisis.National Collaborating Centre for Methods and Tools
Drug Toxicity DeathsStatistics for all Saskatchewan deaths where the cause of death was due to a drug toxicity.Saskatchewan Coroners Service
Opioid Poisoning Crisis in Toronto – UpdateStaff report providing an update on the opioid poisoning crisis and identifying key actions needed urgently to help address the crisis.City of Toronto
Chief Medical Health Officer’s Report 2019Findings from medical charts about the personal, social and medical circumstances of a sample of young adults, women and South Asian men who died from illicit drug toxicity in Fraser Health.Fraser Health
Estimating the size of the fentanyl market in British ColumbiaResearch report estimating the size of the market for fentanyl in British Columbia by calculating what people who use drugs spend on fentanyl or fentanyl-contaminated opioids or stimulants.Cullen Commission of British Columbia on Money Laundering
Interprofessional Education Guidelines on Opioid Use and Opioid Use DisorderInterprofessional education guidelines on opioid use and opioid use disorder.Association of Faculties of Pharmacy of Canada, Canadian Association of Schools of Nursing, Canadian Association for Social Work Education
Drug Checking in British ColumbiaInfographic reporting the results of recent testing.British Columbia Centre on Substance Use
Décès reliés à une intoxication suspectée aux opioïdes ou autres drogues au QuébecData about presumed non-intentional opioid and other drug-related deaths in Quebec. (in French only)Institut national de santé publique du Québec
Indicateurs d’intoxications suspectées aux opioïdes ou autres drogues au Québec : situation en date de juin 2020An examination of non-fatal consequences of opioid use for a comprehensive picture of opioid use in Quebec. Provides data on use of healthcare services related to possible opioid intoxication. (in French only)Institut national de santé publique du Québec
Guide québécois d’amélioration des pratiques sur la prise en charge du trouble lié à l’utilisation des opioïdes (TUO)10 suggestions to improve practices related to the management of people who use opioids, more specifically practices on OUD-related treatment in Quebec (in French only)Institut universitaire sur les dépendances
Working together to better understand, prevent, and manage chronic pain: What We HeardReport on consultations to identify best practices and to gather suggestions for the development of effective strategies to better understand, prevent and manage pain.Canadian Pain Task Force
Opioids and Our ChildrenActivities, resources and recommendations to inform effective and safe use and prescribing of opioids for acute pain in infants, children and youth.Solutions for Kids in Pain and Canadian Foundation for Healthcare Improvement
Opioid Emergency Department VisitsStatistics on opioid poisoning emergency department visits at hospitals in Simcoe Muskoka.Simcoe Muskoka
Brant/Brantford Opioid Information SystemTimely opioid-related information to the public, community partners, and individuals who use substances.Brant County Health Unit
Overdose data for Waterloo RegionLocal and timely information about opioid use and poisonings in the region.Waterloo Region
Opioid ReportingA monthly snapshot of opioid activity in Halton Region.Halton Region
Drug Toxicity Deaths: Saskatchewan, 2010 to 2020Saskatchewan statistics on drug toxicity deaths, 2010–2020.Saskatchewan Coroners Service
Preliminary Patterns in Circumstances Surrounding Opioid-Related Deaths in Ontario during the COVID-19 PandemicStatistics about the circumstances that contributed to opioid-related deaths to inform preventive interventions and policies.Public Health Ontario
Fentanyl-Detected Illicit Drug Toxicity Deaths, January 1, 2012 to September 30, 2020Summary of deaths for which fentanyl or its analogues were detected.BC Coroners Service
2019 Opioids Overdoses: Impacts and StrategiesOutlines the progress made and the challenges witnessed by the OPP, along with statistics, next steps and future priorities.Ontario Provincial Police
Fraser Health Overdose Response Public Report (April–June 2020)Details regional responses and statistics.Fraser Health
Surveillance of Apparent Opioid Overdoses in New Brunswick (2019-Quarter 4)Quarterly surveillance report describes data on apparent opioid overdoses and deaths in New Brunswick, along with data on the take-home naloxone kit distribution and use.New Brunswick Office of the Chief Medical Officer of Health
Alberta Opioid Response Surveillance Report (Q2 2020)Highlights the effects of COVID-19 on unintentional opioid poisonings.Government of Alberta
Evidence on OpioidsEvidence on opioids divided under the topics of pain treatment; misuse, overdose and harms; opioid use disorder; and alternatives to opioids.Canadian Agency for Drugs and Technologies in Health
Association between mothers’ postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort studyPresents the findings of a study that examined the association between mothers’ postoperative opioid prescriptions and opioid-related emergency department presentations or inpatient admissions by their children.Statistics Canada
Life tables, 2016/2018Describes Canadian life expectancy and the probable impact of the opioid crisis.Statistics Canada
Overdose Response Indicator ReportQuarterly report of progress on eight core interventions that form an integrated, comprehensive response to the overdose crisis across the province.BC Centre for Disease Control
Illicit Drug Toxicity Deaths in BCSummarizes all unintentional illicit drug toxicity deaths in British Columbia (accidental and undetermined) that occurred between January 1, 2010, and July 31, 2020, inclusive.British Columbia Coroners Service
Interactive Opioid Tool: Opioid-related morbidity and mortality in OntarAllows users to explore the most recent opioid-related morbidity and mortality data, including emergency department visits, hospitalizations and deaths.Public Health Ontario
Opioid Prescribing by Ontario Dentists 2014–2016Examines opioid prescribing patterns of dentists in Ontario from 2014–2016.Royal College of Dental Surgeons of Ontario
Understanding the Implications of a Shifting Opioid Landscape in OntarioReport summarizing historical patterns of opioid use and overdose to inform future drug policy.Institute for Clinical Evaluation Sciences Report
Stigma and the Opioid Crisis — Final ReportDescription of the findings of an 18-months research project that aimed to develop a better understanding of stigma in an opioid use context, identify learning needs among first responders and establish a measure for evaluating anti-stigma initiatives for first responders.Mental Health Commission of Canada
Research Gaps: Treating Opioid Use DisorderSummary of key findings and evidence gaps identified by CADTH in the context of opioid use disorder treatment.Canadian Agency for Drugs and Technology in Health
Opioid Prescribing in Canada: How Are Practices Changing?Report discusses findings within the context of initiatives and guidelines aimed at reducing harms associated with prescription opioid use.Canadian Institute for Health Information
Canadian Guidelines on Opioid Use Disorder Among Older AdultsClinical guidelines that highlight the issues facing older adults with or at risk for an opioid use disorder and that provides recommendations for the prevention, screening, assessment and treatment of opioid use disorder in older adults.Canadian Coalition for Seniors’ Mental Health
Assessing the Impact of an Opioid Prescribing Guideline for Dentists in Ontario, CanadaReport examining the impact of the opioid prescribing guideline for the dental profession.Ontario Drug Policy Research Network
In Plain SightAn audio series where individuals affected by the opioid crisis share their personal stories.Health Canada
Opioid-related Deaths in Alberta in 2017: Review of Medical Examiner Data,A review of Chief Medical Examiner’s case files in conjunction with administrative data from Alberta Health to learn about the individuals dying from opioid-related deaths, detect patterns, and inform responses.Alberta Health
The Opioid Mortality Surveillance ReportReport outlining trends and characteristics related to confirmed opioid-related deaths in Ontario.Ontario Drug Policy Research Network, Office of the Chief Coroner for Ontario and Public Heath Ontario
National Report: Apparent Opioid-related Deaths in Canada (June 2019)A summary of apparent opioid-related deaths as of May 15, 2019.Public Health Agency of Canada
Employment and Social Assistance Receipt Among Overdose Fatalities in British ColumbiaAn article outlining the employment history and income sources of individuals who experienced a fatal illicit drug overdose between 2007 and 2016 in British Columbia.Statistics Canada
National Report: Apparent Opioid-related Deaths in Canada (April 2019)A summary of apparent opioid-related deaths as of March 2019.Public Health Agency of Canada
Overview of National Data on Opioid-Related Harms and Deaths​​A summary of apparent opioid-related deaths, hospitalizations and emergency room visits as of December 2018.Government of Canada
The Opioid ChaptersThe personal stories of eleven individuals’ experiences with opioids.Ontario Drug Policy Research Network and Health Debate Project
Opioid-Related Deaths in Ontario: Prescribed, Diverted, or Illicit?​An infographic outlining the characteristics of individuals who experienced an opioid-related death in 2016.Ontario Drug Policy Research Network
Ontario Prescription Opioid Tool​An interactive tool that displays trends in opioid prescribing across Ontario from 2012 onwards. Indicators can be displayed by month, year, age group, sex and geography.Ontario Drug Policy Research Network
Women and Prescription OpioidsBrief summary of prescription opioids and considerations unique for womenCentre of Excellence for Women’s Health
Sex, Gender and Opioids​Brief summary of sex and gender differences related to opioid use and its impact.Centre of Excellence for Women’s Health
Facing Addiction in America: The Surgeon General’s Spotlight on Opioids​Summary of the U.S. experience that provides data on prevalence of substance use, opioid misuse, opioid use disorders, and opioid overdoses and related harms, as well as the public health response across the continuum of care.U.S. Department of Health and Human Services
Statement from the Co-Chairs of the Special Advisory Committee on the Epidemic of Opioid Overdoses Regarding Updated Data on Canada’s Opioid CrisisData on opioid-related mortality as of September 2018.Public Health Agency of Canada
Statement from the Co-Chairs of the Special Advisory Committee on the Epidemic of Opioid Overdoses Regarding Updated Data on Canada’s Opioid Crisis​Data on opioid-related mortality as of September 2018.Canadian Institute for Health Information
Pan-Canadian Trends in the Prescribing of Opioid and Benzodiazepines, 2012 to 2017​A chartbook that provides trends in the prescribing of opioids and benzodiazepines for 2017.Canadian Institute for Health Information
National Surveillance of Opioid-related HarmsEmergency Medical Services information from available jurisdictions is provided to allow for examination of suspected opioid-related overdoses in pre-hospital settingsPublic Health Agency of Canada in partnership with the Canadian Institute for Health Information
National report: Apparent opioid-related deaths in Canada (June 2018)​Presents data collected by the provinces and territories on apparent opioid-related deaths.Public Health Agency of Canada in partnership with the Canadian Institute for Health Information
Assessment of the Impact of the Ontario Fentanyl Patch-for-Patch Return Program​A summary of analyses evaluating the impact of the Fentanyl P4P return programPublic Safety Canada
Statement from the Co-Chairs of Special Advisory Committee on the Epidemic of Opioid Overdoses on Updates to Opioid-Related Mortality DataData on opioid-related mortality as of December 2017Public Health Agency of Canada
Starting on Opioids in Ontario​Report on data related to positives and areas for improvement related to ‘new starts’ of opioidsHealth Quality Ontario
Opioid-related Morbidity and Mortality in Ontario
An interactive tool that allows users to explore the most recent opioid-related morbidity and mortality data, including emergency department visits, hospitalizations and deaths
Public Health Ontario
2017 Current Prescribing and Dispensing Landscape in Canada​​Report based on survey findings of Canadian family physicians and community pharmacistsCanada Health Infoway
Results of the Survey on Opioid AwarenessSurvey of Canadians knowledge of opioid issue and risks, and the willingness to act as of November 2017Statistics Canada
Hospitalizations and Emergency Department Visits due to Opioid Poisonings in CanadaA report, infographic and data tablesCanadian Institute for Health Information
Opioid-Related Harms in CanadaReport of community-based prescription data on the number of people receiving opioid prescriptions and the quantity of opioids prescribed in CanadaReport of community-based prescription data on the number of people receiving opioid prescriptions and the quantity of opioids prescribed in Canada
Pan-Canadian Trends in the Prescribing of Opioids, 2012 to 2016​Report of community-based prescription data on the number of people receiving opioid prescriptions and the quantity of opioids prescribed in CanadaCanadian Institute for Health Information