Alcohol is the most commonly used substance in Canada, and understanding its impacts is key to reducing risks. CCSA conducts research, shares knowledge, and develops resources to support evidence-based policies and practices. 

Cannabis is the second most commonly used substance in Canada, legalized in October 2018. CCSA conducts research and provides resources to support evidence-based cannabis policies and practices.

Cocaine use has high health and social costs, making it important to understand its impacts. CCSA synthesizes evidence to support informed policy and practice decisions.

Methamphetamine use is low in Canada, but its availability and associated harms have risen significantly since 2013. CCSA provides research and resources to support evidence-based policies and practices to reduce risks.

Opioids exist in both pharmaceutical and non-pharmaceutical forms, commonly used for pain treatment but also for non-medical purposes. Fentanyl and its analogues are the most widely available opioids in Canada's unregulated drug supply.

Since 2005, the Substance Use in Canada series has highlighted key substance use issues and recommended actions for policy and practice. Guided by CCSA’s Scientific Advisory Council, the reports provide evidence-based insights for policymakers, researchers, educators, and healthcare professionals, with the series name updated to reduce stigma.